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According to a report inThe International Journal of Oncology , founder low dose naltrexone ( LDN ) to genus Cancer patients can better the immune system ’s ability to kill cancerous cells , as well as amend the efficacy of stock cancer treatment and immunotherapy .
This major breakthrough gives research acceptance to what some Doctor have observe in their cancer patient for days , and which was detail in this short filmThe Game Changerproduced for the LDN Research Trust .
The video includes extensive interviews with doctors who have prescribe LDN for Crab patients , as well as researchers , patients , and a chemist . you’re able to happen it at the bottom of this post .
In the video , Dr. Dana Flavin , of the CollMed Foundation , had this to say of LDN ’s impact on immune system : “ Any of my cancer patient who have Cancer the Crab should be on depressed - dosage naltrexone because it is helpful for them in every area of malignant neoplastic disease therapy – period , ” Flavin tell .
“ If I had [ Crab ] myself , I would be on modest - dose naltrexone and I ’m a doctor . And a pharmacologist . And a former FDA official . And I would recommend it to any and every one of my patients . It is imperative as far as I ’m worry as a reinforcement measure and we necessitate to substantiate this . ”
Flavin notes , as does the research , that LDN is not itself a “ cure ” but when used in conjugation with other treatments can help to keep the great unwashed survive cancer and remain in remission .
The following is an excerpt fromThe LDN Book , chapter by Dr. Angus G. Dagleish with Dr. Wai M. Liu . It has been conform for the WWW .
Can LDN Treatment Kill Cancer Cells?
As of this book ’s publishing , there have been only two control clinical trials on low dose naltrexone ( LDN ) and the discussion of cancer : one on white meat cancer , which was send away because of pitiable accrual , and one on glioma , which has finished but is yet to be report on .
Most of the clinical data point with regard to cancer is therefore anecdotal or small serial publication . A pioneer of the exploration of the use of LDN in treat legion unlike experimental condition was Dr. Bihari , who as of March 2014 was reported as having treated 354 patients .
According to theLDN website , he claimed an objective response ofapproximately 20 % and stabilization in approximately 25 % .
If these were the results of a rigorous randomized trial, without other treatments, they would be most impressive, even by the standards of the newer, more active candidates of today.
I was fortunate to bring down the clinic once and to have show numerous anecdotes , but I matte at the time that the data include too many other co - treatments to excuse the title about LDN .
However , in 2002 an oncologist and an helper from the National Cancer Institute reexamine thirty charts from Dr. Bihari ’s situation , of which one-half were chosen as look , without interrogative , to have responded to LDN , confirm thatthere are several anecdotes where LDN come along to be the only major therapy that has led to clinical responses or retentive - full term stabilization of the disease .
My own personal experience [AGD] with LDN treatment has included high-risk patients with multiple liver metastases who have failed standard chemotherapy, which has led to both long-term disease-free status and long-term stable disease.
I also believeLDN has contribute to stabilization of aggressive disease in affected role who have had tumor types other than melanoma , including forward-looking ovarian Crab and advanced prostate cancer .
In addition , two patients who had both progressed through standard treatment for stage IV glioma had remarkable stabilisation on LDN for six months , having progressed even during standard radiation and chemotherapy .
However, it was the appearance of marked whole body vitiligo in a melanoma patient who started on LDN that raised the question of an alternative mode of action.
He had progressed abide by a disease - free period of most four age , on an immunotherapy program given for nonresectable recurrence of a melanoma in the headspring and neck involving the cervix lymph nodes .
Upon return of his pulmonary metastasis , he was commenced on LDN and within one week developed severe whole trunk vitiligo , which is a characteristic consistent with trigger cytotoxic T cellular telephone recognizing tyrosinase .
Anti-Cancer Properties of Naltrexone
It has been present , principally through the work of Dr. [ Ian ] Zagon , thatlow doses of naltrexone are equal to of suppressing tumor growth.2
A definitive mechanism of action has yet to be established, but the effect could be achieved through direct antagonism of tumor growth or via modifications to the host immune system.
neoplasm outcome is a counterpoise of growth and demise , and naltrexone — as well as other opiate and opiate opponent — is capable of altering this counterweight .
In addition to their universally accepted analgetic lineament , opioids have also been report to elicit a turn of other cellular response that head to neoplasm decease .
The diversity of these effects has made it difficult to establish a major cause, and serves only to confound the identification of the principal mechanism of action.
Indeed , they include those that are pro - survival in nature such as the elicitation of proliferation and protection against cell death , as well as arctic opposite gist , including increment inhibition and the trigger of apoptosis .
The ultimate consequences of handling with naltrexone are determined by venereal disease and docket . Nevertheless , study exist to seek to best delineate the legal action of the opioids and their cognate receptors , and in doing so design fresh therapeutic strategies to best utilize this fascinating class of chemical compound .
In the early 1960s, it was reported that morphine possessed the capacity to disrupt the normal physiology of tumor-bearing rats.3
The sketch was take in charge primarily to explore the appetite - troubled nature of morphia on brute with neoplasm .
However , in addition to showing that morphine could reduce the weight of these animals , the study also showed that tumor weights were concomitantly increase in those mice pass on morphine .
The reason for this gain in tumour size was unclear , but it was graspable that morphia could have secondary effects on the resistant system , rendering the host more favorable to cancer growth .
Indeed, morphine has been shown to be immunomodulatory in some instances, and thus it can alter the quality of the adaptive immune response.4
or else , the increment in tumor size could simply have been due to a unmediated effect of morphine that leave in enhanced cellular proliferation or in reduced cellular telephone death .
The induction of apoptosis is a biological necessity and forms parts of embryotic development and normal homeostasis , and as such , disruptions can lead to a variety of diseases and disorders.5
Morphine has been shown to singly prevent both normal and hope cell expiry in the ciliary ganglion of the chick fertilized egg , evoke that in summation to modulating neurotransmission , morphine and other endogenous opiates may regulate neurophysiology.6
In this case, the concentration of morphine appeared to be important, as apoptosis was only disrupted when used at higher doses; no effect was seen at lower doses.
The importance of tightness was corroborate by another survey , this meter on rat , which showed higher morphine concentrations ( 25–200 micromolar [ μM ] ) were capable to protect primary rat neonatal astrocytes from apoptosis induced by nitric oxide.7
In this study , it was also noted that the mechanism involved , in part , transition of the PI3 - kinase ( PI3 - K ) cascade .
This start the doors to the possibleness thatmorphine and other opioids might be able-bodied to shape the emergence and survival of the fittest of Crab cells . This was indeed the case , and a number of review clause have summarized the influence that morphine has on tumor fate.8
Unfortunately, the literature is still unclear and in many cases is contradictory.
Reports simultaneously show that morphia is capable to subdue the growth of cancer cells as well as stimulate their outgrowth in vitro .
The cancer cells studied have been varied , representing virtually all cancer types , and all have been shown to be responsive . As some of these cancer mobile phone lines express relatively low levels of the opioid receptors,9one suspect the effects may be both dependent and independent of these receptors .
Furthermore , as both pro- and anti - cancer upshot were see in fauna mannikin , it has been postulated that the impact of morphine on the resistant arrangement is also likely to find out neoplasm fate.10
However, the conclusions of a recent review added to the confusion by saying the evidence of an effect on anti-tumor immunity was inconclusive.11
The effect of morphia on angiogenesis also can not be discounted12and only reinforces the eyeshot that in addition to sense organ - dependent mechanisms , opioids may charm cellular fate in other ways .
LDN As An Anti-Cancer Agent
There is a good scientific reason to take LDN severely as having a potential role as an anti - cancer federal agent .
First , it is an anti - seditious , a stratum of agents that have been show to better malignant neoplastic disease outcomes as usher by legion aspirin and COX-2 inhibitor bailiwick as well as the surprising benefit reported with statin drug .
Second , LDN appears to have a marked resistant modulatory response leading to an increment in innate immunity(such as natural killer cell body process ) with a possible knock - on essence on CD8 adaptive T cells ( the appearance of vitiligo after commencing LDN can only be explain by the induction of CD8 cells against tyrosinase ) .
Third, cancer patients can be suppressed by their disease, its treatments, and the psychological effects of living with a lethal condition.
patient account a remarkable benefit from commence LDN with paying attention to their psychological status , feel much well than on late treatments , which may be due to its elusive essence on various opiate receptors .
next research must focus on LDN ’s role as an additive agent with other treatments , as it can be add to most other treatment ( with the elision of opiate ) and , in the case of oncology , it appear to heighten the effects of some other treatments such as platinum .
There is a very gamy chance that it will be most effectual in some subtle combination .
It is already trade with alpha lipoic acid and has been reported to be enhanced by the addition of metencephalin or OGF . However , the true welfare of these combination continue to be shown in clinical trial run .
Some combinations make perfect sense, such as making sure the recipient is vitamin D3 replete.
Low vitamin D spirit level have been suggested as a major cause for nonresponse to LDN in multiple sclerosis patients , and low levels of vitamin D greatly subjugate the efficaciousness of anti - tuberculosis chemotherapy and melanoma treatment .
mechanics of action discuss antecedently strongly suggest welfare potential with immunotherapy such as vaccine , cytokines , and maybe checkpoint inhibitors . Similarities already mention suggest a enceinte potential difference in combining LDN with the cannabinoids , to name but one deterrent example .
In sum-up , there are many reasons for developing LDN as an anti - cancer agent either as an ancillary or in combination with other agents .
Unfortunately, the numerous anecdotes currently reported still require confirmation with properly conducted clinical trials, which are very expensive.
The monetary value of clinical trials is the major intellect why they have not been done to date , as the intellectual property , based on current patent filings ( over 350 ) , is not secure enough to protect development .
It is go for that this can be address in the near hereafter and that LDN can achieve a licence for adjuvant use in cancer direction .
Watch
“ The Game Changer ” – LDN & CancerfromLDN Research TrustonVimeo .
Notes
Recommended Reads
Plant and Mushroom Medicines for Cancer
Treating Addiction : From Opium Poppy to Morphine to Naltrexone
The LDN Book
How a Little - Known Generic Drug Low Dose Naltrexone Could Revolutionize Treatment for Autoimmune Diseases , Cancer , Autism , Depression , and More
$ 27.99
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